By Serena McNiff
Whereas it is not clear exactly how SARS-CoV-2 causes clots, a brand new examine means that the quantity of a specific protein — referred to as issue V — in a affected person’s blood might have one thing to do with it.
In March, researchers at Massachusetts Normal Hospital obtained a blood pattern from a affected person with extreme COVID-19 and seen one thing uncommon. The affected person’s blood had considerably above-normal ranges of issue V.
Researchers then studied greater than 100 sufferers handled within the intensive care unit for COVID-19.
Excessive ranges of issue V have been discovered throughout the group, and practically half of the sufferers had above-normal ranges. When researchers in contrast the samples to historic data, greater than 1 in 10 sufferers had greater issue V ranges than had been seen earlier than on the hospital.
“Except for COVID-19, I’ve by no means seen the rest trigger markedly elevated issue V, and I have been doing this for 25 years,” examine co-author Dr. Elizabeth Van Cott mentioned in a hospital information launch. She is a pathology investigator at Mass Normal and a pathology professor at Harvard Medical College.
The examine discovered that sufferers with elevated issue V have been extra more likely to have blood clots within the lungs, referred to as pulmonary embolism, and deep vein thrombosis (DVT), or clots within the veins.
Of sufferers with excessive ranges of issue V, one-third had both DVT or a pulmonary embolism, in contrast with 13% of sufferers with decrease ranges.
Whereas sufferers with excessive issue V ranges have been at larger threat for clotting issues, sufferers with decrease issue V ranges had the next threat of dying, researchers discovered.
A lower in issue V ranges may point out sufferers are progressing to a severe and infrequently deadly situation wherein clotting processes develop into overactive, Van Cott and colleagues mentioned.
They mentioned the findings might assist establish which sufferers are at elevated threat of blood clots and dying.
The findings have been just lately revealed on-line within the American Journal of Hematology.