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IVF Will not Increase Ovarian Most cancers Threat: Research


By Robert Preidt
HealthDay Reporter

THURSDAY, Nov. 19, 2020 (HealthDay Information) — Fertility remedies corresponding to in vitro fertilization do not seem to extend a girl’s threat of ovarian cancer, a brand new examine finds.

Earlier research advised that ladies who used this assisted reproductive applied sciences (ART) corresponding to IVF to get pregnant could also be in danger for ovarian cancer and non-malignant borderline tumors, as a consequence of elevated ranges of intercourse hormones wanted to stimulate egg manufacturing, in addition to a number of punctures disrupting ovarian tissue.

ART entails eradicating eggs from a girl’s ovaries surgically, fertilizing them in a lab after which inserting them within the womb.

On this examine, researchers analyzed information from the Netherlands to check greater than 30,600 ladies who obtained ovarian stimulation for ART between 1983 and 2001 and practically 10,000 infertile ladies who did not obtain such therapy.

After a median follow-up of 24 years, the ladies had 158 invasive cancers and 100 borderline ovarian tumors. (Median means half had been adopted longer, half for much less time.)

Considerably, ladies who had ART didn’t have a better most cancers threat than infertile ladies who didn’t have ART — even after greater than 20 years had handed.

In contrast with ladies within the common inhabitants, ladies who used ART did have a better ovarian most cancers threat.

Researchers stated this was primarily as a result of a better proportion of ladies who obtained ART by no means had kids. Childlessness has been proven to be a powerful threat issue for ovarian most cancers, in line with authors of the examine printed Nov. 17 in JNCI: Journal of the Nationwide Most cancers Institute.

Additionally they discovered that the danger of ovarian cancer decreased amongst ladies with a bigger variety of profitable ART cycles that resulted in childbirth.

In contrast with ladies within the common inhabitants and infertile ladies who did not have ART, ladies who had ART had virtually double the chances for borderline ovarian tumors, in line with the examine.

However the threat did not rise after extra therapy cycles or longer follow-up, suggesting that it would owe to underlying affected person traits reasonably than ART itself, in line with the researchers.


Borderline tumors are uncommon within the common inhabitants and customarily straightforward to deal with, they famous.

“Reassuringly, ladies who obtained ovarian stimulation for assisted reproductive know-how do not need an elevated threat of malignant ovarian most cancers, not even in the long term,” stated lead writer Flora van Leeuwen, an epidemiologist on the Netherlands Most cancers Institute in Amsterdam.

“Nonetheless, it is very important notice that even with the lengthy follow-up in our examine, the median age of the ladies at finish of follow-up was solely 56 years,” she stated in a journal information launch.

Noting that the incidence of ovarian most cancers within the inhabitants will increase at older ages, van Leeuwen stated it is very important observe ladies who’ve had ART even longer.

Extra data

For extra on ovarian most cancers, see the American Cancer Society.

SOURCE: JNCI: Journal of the Nationwide Most cancers Institute, information launch, Nov. 17, 2020

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